Introduction
Our client is a leading national research and innovation organization advancing human health through cutting-edge biotherapeutics and vaccines, offering the stability of the public sector with the innovation of a high-tech biotech environment.
As an Upstream Processing (USP) Technician , you will support the manufacture of clinical biologics under current Good Manufacturing Practices (cGMP). You’ll work hands-on with mammalian cell culture, bioreactors, and upstream operations to produce material for clinical studies in a highly regulated, team-oriented environment.
Responsibilities
- Execute upstream manufacturing steps according to batch records and cGMP requirements
- Perform mammalian cell culture operations, including propagation, expansion, and clinical-scale production in bioreactors
- Carry out in-process testing using spectrophotometers, pH meters, metabolite analyzers, and related lab equipment
- Perform master cell bank manufacturing and filling under biosafety cabinet conditions
- Weigh, transfer, and mix chemicals and media components according to procedures
- Set up, install, and operate single-use assemblies and related upstream processing equipment
- Conduct product filtration, centrifugation, and related upstream clarification steps
- Prepare and organize glassware and disposable assemblies for production runs
- Verify instrument calibration status prior to each production batch and document results
- Complete and review logbooks and other GMP documentation, performing corrections as required
- Support cleaning and autoclave activities in collaboration with production support teams
- Monitor stocks of common lab supplies and notify management of inventory needs
- Respond to emergency notifications following established procedures
- Participate in CAPA, Change Control, and Deviation reporting activities as needed
Requirements
- Diploma or degree in Biotechnology, Biology, Biochemistry, or related life science (or equivalent experience in GMP manufacturing)
- Experience with mammalian cell culture and aseptic techniques (academic, co-op, or industry)
- Familiarity with cGMP, batch records, and controlled documentation practices
- Comfort working with bioreactors, filtration systems, and common analytical instruments (e.g., pH meters, spectrophotometers)
- Strong attention to detail and commitment to data integrity and product quality
- Ability to follow SOPs precisely and maintain accurate documentation
- Team-oriented mindset with good communication skills and willingness to support cross-functional activities
- Flexibility to work in a regulated, production-driven environment (shift work or occasional off-hours may be required)
What We Offer
Why apply through Brunel? Finding the next step in your career can be a full-time job in itself. We manage the process for you: from submitting your resume to coordinating interviews to extending offers and assisting with onboarding. We’ll get you going while you get on with the job.
About Us
Brunel has a reputation for working with some of the best in the business. That’s what we continually strive for. Over 45 years, we’ve created a global network of interesting clients and talented individuals working together through a vast array of services.